Also, PP242 was demonstrated to induce ERK activation in MM cell strains and Principal cells, which wasn't correlated with S6K inhibition nor was it prevented by PI3K inhibition. ERK activation is often prevented by MEK inhibitors which is linked to concurrent stimulation of Raf kinase action but not Ras activation. https://rafaelcwogx.wizzardsblog.com/28555430/the-delafloxacin-diaries