Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, which... https://lucianoc691ced2.idblogz.com/profile